Herquline B, a New Platelet Aggregation Inhibitor Produced by Penicillium herquei Fg-372.

Novel Platelet Aggregation Inhibitor Produced by Chromobacterium sp . QS 3666

A novel platelet aggregation inhibitor, YM-254890, was isolated from the culture broth of strain QS3666. This strain was isolated from a soil sample collected at Okutama, Tokyo, Japan, and was identified as Chromobacterium sp. by morphological and physiological criteria. YM254890 was purified from the culture supernatant by solvent extraction, ODS and silica gel flash chromatography, followed b...

Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717.

A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1, 4-perhydrooxazine-2,5-dione by NMR analysis, X-ray crystallographic analysis and chemical synthesis. Bassia...

PI-083, a new platelet aggregation inhibitor.

Active polyketides isolated from Penicillium herquei.

In this work we are reporting the isolation by classical methods of chromatography of six polyketides from Penicillium herquei. The compounds citreorosein ( 1) , emodin ( 2) , janthinone ( 3) , citrinin ( 4) , citrinin H1 ( 5) and dicitrinol ( 6) were identified by spectral methods of 1D and 2D NMR and MS. Compounds 1, 2 and 3 were tested against promastigotes forms of Leishmania brasiliensis a...

Phenylpyropene C, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959.

Acyl-CoA: cholesterol acyltransferase (ACAT, EC 2.3.1.26) is responsible for intracellular esterification of cholesterol and plays a key role in intestinal absorption of cholesterol, hepatic production of lipoproteins1,2) and accumulation of cholesteryl esters within macrophages and smooth muscle cells of the atheroma3). Therefore, ACAT is an attractive target for new treatments of hypercholest...